The prostaglandins.

Abstract

The introduction of dinoprost tromethamine (Prostin F2 Alpha) as an abortifacient in the second trimester of pregnancy represents the first clinical use of a prostaglandin. Various synthetic analogues of the naturally occurring derivatives are being employed investigationally in the treatment of peptic ulcer, hypertension, asthma, and hypercalcemia. In the United States, dinoprost tromethamine is primarily administered intra-amniotically. Despite the fact that a substantial number of patients experience allergic reactions, hypertension, bronchospasm, nausea, vomiting, cramps, and diarrhea, the efficacy and relative safety of dinoprost tromethamine establish it as superior to intra-amniotic instillation of hypertonic saline. Cervical laceration, laceration or rupture of the lower uterine segment, retention of the placenta, and hemorrhage in part reflect the intensity of uterine contraction induced by dinoprost. Experience in administration improves the therapeutic response and diminishes adverse reactions.

• Authors: C B Clayman
• Journal: JAMA (JAMA) Vol. 233 Issue 8 Pg. 904-6 (Aug 25 1975) ISSN: 0098-7484 [Print] United States
• PMID: 1173907 (Publication Type: Journal Article)

Chemical References

• Abortifacient Agents
• Prostaglandins F
• Dinoprost
• dinoprost tromethamine

Topics

• Abortifacient Agents (administration & dosage)
• Bronchial Spasm (chemically induced)
• Diarrhea (chemically induced)
• Dinoprost (analogs & derivatives)
• Dose-Response Relationship, Drug
• Drug Evaluation
• Drug Hypersensitivity (etiology)
• Female
• Humans
• Hypertension (chemically induced)
• Injections (methods)
• Muscle Contraction (drug effects)
• Myometrium (drug effects)
• Nausea (chemically induced)
• Pregnancy
• Pregnancy Trimester, Second
• Prostaglandins F (administration & dosage, adverse effects, pharmacology)
• Vomiting (chemically induced)