5-demethylovalicin, as a methionine aminopeptidase-2 inhibitor produced by Chrysosporium.

Abstract

5-Demethylovalicin was isolated from the fermentation broth Chrysosporium lucknowense and the structure was identified by spectroscopic methods. 5-Demethylovalicin inhibited the recombinant human MetAP-2 (IC(50)=17.7 nM) and the growth of human umbilical vein endothelial cells (HUVEC; IC(50)=100 nM) in cell proliferation assay without cytotoxicity on the transformed and cancer cell lines.

• Authors: Kwang-Hee Son, Ju-Young Kwon, Ha-Won Jeong, Hyae-Kyeong Kim, Chang-Jin Kim, Yie-Hwa Chang, Jung-Do Choi, Byoung-Mog Kwon
• Journal: Bioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 10 Issue 1 Pg. 185-8 (Jan 2002) ISSN: 0968-0896 [Print] England
• PMID: 11738620 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 5-demethylovalicin
• Enzyme Inhibitors
• Recombinant Proteins
• Sesquiterpenes
• Aminopeptidases
• methionine aminopeptidase 2
• Metalloendopeptidases

Topics

• Aminopeptidases (antagonists & inhibitors)
• Cells, Cultured
• Chrysosporium (metabolism)
• Enzyme Inhibitors (pharmacology)
• Humans
• Metalloendopeptidases (antagonists & inhibitors)
• Recombinant Proteins (antagonists & inhibitors)
• Sesquiterpenes (pharmacology)