Delayed treatment with polynitroxyl albumin reduces infarct size after stroke in rats.

Abstract

Nitroxides are antioxidants that are known to protect cells from oxidative damage. Polynitroxyl albumin (PNA) is a compound of human serum albumin covalently labeled with nitroxides that exhibits a prolonged half-life and an enhanced antioxidant activity. Adult male Sprague-Dawley rats were subjected to 90 min intraluminal middle cerebral artery occlusion and the drug was administered intravenously immediately or 2 h after reperfusion. The effects of the drug were evaluated 24 h after reperfusion. Infarct volume was significantly reduced in immediate (79% reduction) and delayed (53% reduction) PNA-treated groups. The efficacy of a single, delayed i.v. injection of PNA suggests that PNA has great promise in the treatment of acute human stroke.

• Authors: T Sugawara, F Yu, L Ma, C J Hsia, P H Chan
• Journal: Neuroreport (Neuroreport) Vol. 12 Issue 16 Pg. 3609-12 (Nov 16 2001) ISSN: 0959-4965 [Print] England
• PMID: 11733721 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Albumins
• Contrast Media
• Nitrogen Oxides
• polynitroxyl-albumin

Topics

• Albumins (therapeutic use)
• Animals
• Contrast Media (therapeutic use)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Infarction, Middle Cerebral Artery (drug therapy, pathology)
• Male
• Nitrogen Oxides (therapeutic use)
• Rats
• Rats, Sprague-Dawley
• Stroke (drug therapy, pathology)