Effects of apomorphine, ergocornine and piribedil on audiogenic seizures in DBA/2 mice.

Abstract

Audiogenic seizures in DBA/2 mice have been studied after administration of drugs believed to act as dopamine agonists. Apomorphine at 0.4 mg/kg delays all phases of the response, the tonic phase is absent after 2.0 mg/kg; the clonic phase is abolished by 10 mg/kg. Ergocornine (0.5-8.0 mg/kg) produces effects on the latency and occurrence of seizure stages similar to those of apomorphine. Piribedil, ET 495 (4-100 mg/kg) is less potent; even after 100 mg/kg clonic and tonic phases occurred in 50% of the mice.

• Authors: G M Anlezark, B S Meldrum
• Journal: British journal of pharmacology (Br J Pharmacol) Vol. 53 Issue 3 Pg. 419-21 (Mar 1975) ISSN: 0007-1188 [Print] England
• PMID: 1173346 (Publication Type: Journal Article)

Chemical References

• Ergolines
• Piperazines
• Receptors, Drug
• Piribedil
• Apomorphine

Topics

• Acoustic Stimulation
• Animals
• Apomorphine (pharmacology)
• Ergolines (pharmacology)
• Exploratory Behavior (drug effects)
• Male
• Mice
• Mice, Inbred DBA
• Motor Activity (drug effects)
• Piperazines (pharmacology)
• Piribedil (pharmacology)
• Receptors, Drug
• Seizures (physiopathology)