Brooke-Spiegler syndrome.

Abstract

The Brooke-Spiegler syndrome is an autosomal dominant one characterized by cylindromas, trichoepitheliomas and occasionally spiradenomas. Within a given family, some members may have cylindromas whereas others may have trichoepitheliomas or both. We describe the coexistence of trichoepithelioma papulosum multiplex (also known as epithelioma adenoides cysticum of Brooke) and cylindromas in a 30-year-old man, and discuss the relationship between these two autosomal dominant syndromes.

• Authors: J C Szepietowski, F Wasik, G Szybejko-Machaj, A Bieniek, R A Schwartz
• Journal: Journal of the European Academy of Dermatology and Venereology : JEADV (J Eur Acad Dermatol Venereol) Vol. 15 Issue 4 Pg. 346-9 (Jul 2001) ISSN: 0926-9959 [Print] England
• PMID: 11730050 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Carcinoma, Adenoid Cystic (genetics, pathology)
• Head and Neck Neoplasms (genetics, pathology)
• Humans
• Male
• Neoplasms, Basal Cell (genetics, pathology)
• Neoplasms, Multiple Primary (genetics, pathology)
• Neoplastic Syndromes, Hereditary (pathology)
• Skin Neoplasms (genetics, pathology)