Sympathetic nervous system and experimental diabetes: role of adrenal medullary hormones.

Abstract

The sympathetic nervous system is of major importance in the regulation of various physiological functions. The present review discusses the mechanisms which control glucose homeostasis and the role of the sympathetic nervous system in experimental diabetes with special emphasis on the role of adrenal medullary hormones, over-activity of the sympathetic nervous system and its relationship to hypertension in the diabetic state and the effect of stress. The chapter also reviews the ability of various drugs and pharmacological agents to produce hyperglycemia in experimental animals and how this information can be used in screening new chemical entities and in differentiating the mode of action of these agents.

• Authors: C L Kaul, P Ramarao
• Journal: Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques (Prog Drug Res) Vol. 57 Pg. 163-80 ( 2001) ISSN: 0071-786X [Print] Switzerland
• PMID: 11728001 (Publication Type: Journal Article, Review)

Chemical References

• Adrenergic alpha-Antagonists
• Adrenergic beta-Antagonists
• Blood Glucose
• Catecholamines
• Insulin
• Prostaglandins

Topics

• Adrenal Medulla (physiology)
• Adrenergic alpha-Antagonists (pharmacology)
• Adrenergic beta-Antagonists (pharmacology)
• Animals
• Blood Glucose (drug effects)
• Catecholamines (physiology)
• Diabetes Mellitus, Experimental (physiopathology)
• Hyperglycemia (chemically induced)
• Insulin (metabolism)
• Insulin Secretion
• Prostaglandins (pharmacology)
• Sympathetic Nervous System (physiopathology)