Cancer chemopreventive activity of odorine and odorinol from Aglaia odorata.

Abstract

In the course of our continuing search for novel cancer chemo-preventive agents from natural sources, we have carried out a primary screening in vitro assay of the compounds isolated from Aglaia odorata. Consequently, aminopyrrolidine-diamides, odorine and odorinol, were obtained as active constituents. These compounds exhibited potent anti-carcinogenic effects in a two-stage carcinogenesis test of mouse skin induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. Further, both compounds showed remarkable inhibitory effects in two-stage mouse skin carcinogenesis models induced by nitric oxide (NO) donors such as (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexenamide (NOR-1) or peroxynitrite as an initiator and TPA as a promoter. From these results, it was concluded that odorine and odorinol inhibited both the initiation and promotion stages of two-stage skin carcinogenesis.

• Authors: A Inad, H Nishino, M Kuchide, J Takayasu, T Mukainaka, Y Nobukuni, M Okuda, H Tokuda
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 24 Issue 11 Pg. 1282-5 (Nov 2001) ISSN: 0918-6158 [Print] Japan
• PMID: 11725964 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Drugs, Chinese Herbal
• Pyrrolidines
• odorinol

Topics

• Animals
• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, therapeutic use)
• Carcinogenicity Tests (methods)
• Drug Evaluation, Preclinical (methods)
• Drugs, Chinese Herbal (chemistry, isolation & purification, therapeutic use)
• Female
• Meliaceae (chemistry)
• Mice
• Mice, Inbred SENCAR
• Papilloma (chemically induced, prevention & control)
• Phytotherapy (methods)
• Plant Leaves (chemistry)
• Pyrrolidines (chemistry, isolation & purification, therapeutic use)
• Skin Neoplasms (chemically induced, prevention & control)