| Abstract | In the course of our continuing search for novel cancer chemo-preventive agents from natural sources, we have carried out a primary screening in vitro assay of the compounds isolated from Aglaia odorata. Consequently, aminopyrrolidine-diamides, odorine and odorinol, were obtained as active constituents. These compounds exhibited potent anti-carcinogenic effects in a two-stage carcinogenesis test of mouse skin induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. Further, both compounds showed remarkable inhibitory effects in two-stage mouse skin carcinogenesis models induced by nitric oxide (NO) donors such as (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexenamide (NOR-1) or peroxynitrite as an initiator and TPA as a promoter. From these results, it was concluded that odorine and odorinol inhibited both the initiation and promotion stages of two-stage skin carcinogenesis. |
| Authors | A Inad, H Nishino, M Kuchide, J Takayasu, T Mukainaka, Y Nobukuni, M Okuda, H Tokuda
(Affiliation: Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan. inada at pharm.setsunan.ac.jp)
|
| Journal | Biological & pharmaceutical bulletin
(Biol Pharm Bull)
Vol. 24
Issue 11
Pg. 1282-5
(Nov 2001)
ISSN: 0918-6158 Japan |
| PMID | 11725964
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Antineoplastic Agents, Phytogenic
- Drugs, Chinese Herbal
- Pyrrolidines
- odorinol
|
| Topics |
- Animals
- Antineoplastic Agents, Phytogenic
(chemistry, isolation & purification, therapeutic use)
- Carcinogenicity Tests
(methods)
- Drug Evaluation, Preclinical
(methods)
- Drugs, Chinese Herbal
(chemistry, isolation & purification, therapeutic use)
- Female
- Meliaceae
(chemistry)
- Mice
- Mice, Inbred SENCAR
- Papilloma
(chemically induced, prevention & control)
- Phytotherapy
(methods)
- Plant Leaves
(chemistry)
- Pyrrolidines
(chemistry, isolation & purification, therapeutic use)
- Skin Neoplasms
(chemically induced, prevention & control)
|
