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Cancer chemopreventive activity of odorine and odorinol from Aglaia odorata.

Abstract
In the course of our continuing search for novel cancer chemo-preventive agents from natural sources, we have carried out a primary screening in vitro assay of the compounds isolated from Aglaia odorata. Consequently, aminopyrrolidine-diamides, odorine and odorinol, were obtained as active constituents. These compounds exhibited potent anti-carcinogenic effects in a two-stage carcinogenesis test of mouse skin induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. Further, both compounds showed remarkable inhibitory effects in two-stage mouse skin carcinogenesis models induced by nitric oxide (NO) donors such as (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexenamide (NOR-1) or peroxynitrite as an initiator and TPA as a promoter. From these results, it was concluded that odorine and odorinol inhibited both the initiation and promotion stages of two-stage skin carcinogenesis.
AuthorsA Inad, H Nishino, M Kuchide, J Takayasu, T Mukainaka, Y Nobukuni, M Okuda, H Tokuda
JournalBiological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 24 Issue 11 Pg. 1282-5 (Nov 2001) ISSN: 0918-6158 [Print] Japan
PMID11725964 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Drugs, Chinese Herbal
  • Pyrrolidines
  • odorinol
Topics
  • Animals
  • Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, therapeutic use)
  • Carcinogenicity Tests (methods)
  • Drug Evaluation, Preclinical (methods)
  • Drugs, Chinese Herbal (chemistry, isolation & purification, therapeutic use)
  • Female
  • Meliaceae (chemistry)
  • Mice
  • Mice, Inbred SENCAR
  • Papilloma (chemically induced, prevention & control)
  • Phytotherapy (methods)
  • Plant Leaves (chemistry)
  • Pyrrolidines (chemistry, isolation & purification, therapeutic use)
  • Skin Neoplasms (chemically induced, prevention & control)

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