Experience of 10 years with Churg-Strauss syndrome: An accompaniment to or a transition from aspirin-induced asthma?

Abstract	Churg-Strauss syndrome is a rare, idiopathic, eosinophilic vasculitis appearing in concurrence with asthma which is often severe. Aspirin-induced asthma is a special clinical syndrome existing in nearly 10 % of adult asthmatics. After leukotriene antagonists had been marketed there has been marked increase in Churg-Strauss syndrome reports among the patients who had been followed up with asthma. This syndrome seems to be more frequent among the patients with aspirin-induced asthma. The role of leukotriene antagonists on the conversion from aspirin-induced asthma to Churg-Strauss syndrome has aroused attention and been questioned. Here we report 7 cases of Churg-Strauss syndrome where three had aspirin induced asthma which we have diagnosed in the last 10 years and where only one of them seems to be related to antileukotriene drug use.
Authors	A Kalyoncu, G Karakaya, A Sahin, M Artvinli
Journal	Allergologia et immunopathologia (Allergol Immunopathol (Madr)) 2001 Sep-Oct Vol. 29 Issue 5 Pg. 185-90 ISSN: 0301-0546 [Print] Singapore
PMID	11720651 (Publication Type: Case Reports, Journal Article)
Chemical References	Acetates Adrenal Cortex Hormones Analgesics Anti-Asthmatic Agents Anti-Inflammatory Agents Cyclopropanes Leukotriene Antagonists Quinolines Steroids Sulfides montelukast Aspirin
Topics	Acetates (adverse effects) Adrenal Cortex Hormones (adverse effects, therapeutic use) Adult Aged Analgesics (adverse effects) Anti-Asthmatic Agents (adverse effects) Anti-Inflammatory Agents (adverse effects, therapeutic use) Aspirin (adverse effects) Asthma (chemically induced, complications, drug therapy) Cholecystitis (etiology) Churg-Strauss Syndrome (chemically induced, complications, drug therapy) Cyclopropanes Diabetes Mellitus (chemically induced) Eosinophilia (etiology) Fatal Outcome Female Heart Arrest (complications) Humans Leukotriene Antagonists (adverse effects) Male Middle Aged Multiple Myeloma (complications) Osteoporosis (chemically induced) Quinolines (adverse effects) Steroids Sulfides

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