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10-Demethoxystegane, a new lignan from Steganotaenia araliacea.

Abstract
A new dibenzocyclooctadiene lactone lignan, 10-demethoxystegane (1), together with the known compounds steganone (2) and prestegane B (3), have been isolated from the organic extract of Steganotaenia araliacea(Apiaceae). Steganone (2) showed antiproliferative activity against an ovarian cancer cell line (OVCAR-3).
AuthorsK M Meragelman, T C McKee, M R Boyd
JournalJournal of natural products (J Nat Prod) Vol. 64 Issue 11 Pg. 1480-2 (Nov 2001) ISSN: 0163-3864 [Print] United States
PMID11720541 (Publication Type: Journal Article)
Chemical References
  • 10-demethoxystegane
  • Antineoplastic Agents, Phytogenic
  • Lignans
  • steganone
  • prestegane B
  • 4-Butyrolactone
Topics
  • 4-Butyrolactone (analogs & derivatives, chemistry, isolation & purification, pharmacology)
  • Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
  • Apiaceae (chemistry)
  • Chromatography, High Pressure Liquid
  • Colonic Neoplasms
  • Female
  • Humans
  • Inhibitory Concentration 50
  • Lignans (chemistry, isolation & purification, pharmacology)
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Ovarian Neoplasms
  • Plants, Medicinal (chemistry)
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Tumor Cells, Cultured (drug effects)

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