Caspase-10 is an initiator caspase in death receptor signaling.

Abstract	A role for caspase-10, previously implicated in the autoimmune lymphoproliferative syndrome, in death receptor signaling has not been directly shown. Here we show that caspase-10 can function independently of caspase-8 in initiating Fas- and tumor necrosis factor-related apoptosis-inducing ligand-receptor-mediated apoptosis. Moreover, Fas crosslinking in primary human T cells leads to the recruitment and activation of caspase-10. Fluorescent resonance energy transfer analysis indicates that the death-effector domains of caspase-8 and -10 both interact with the death-effector domain of FADD. Nonetheless, we find that caspase-8 and -10 may have different apoptosis substrates and therefore potentially distinct roles in death receptor signaling or other cellular processes.
Authors	J Wang, H J Chun, W Wong, D M Spencer, M J Lenardo
Journal	Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 98 Issue 24 Pg. 13884-8 (Nov 20 2001) ISSN: 0027-8424 [Print] United States
PMID	11717445 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Adaptor Proteins, Signal Transducing Apoptosis Regulatory Proteins Carrier Proteins FADD protein, human Fas-Associated Death Domain Protein Membrane Glycoproteins TNF-Related Apoptosis-Inducing Ligand TNFSF10 protein, human Tumor Necrosis Factor-alpha fas Receptor CASP8 protein, human CASP9 protein, human Caspase 10 Caspase 8 Caspase 9 Caspases CASP10 protein, human
Topics	Adaptor Proteins, Signal Transducing Apoptosis Apoptosis Regulatory Proteins B-Lymphocytes (cytology) Carrier Proteins (metabolism) Caspase 10 Caspase 8 Caspase 9 Caspases (genetics, metabolism) Cells, Cultured Dendritic Cells (cytology) Dimerization Enzyme Activation Fas-Associated Death Domain Protein Gene Expression Profiling Humans Jurkat Cells Membrane Glycoproteins (metabolism) Signal Transduction T-Lymphocytes (cytology) TNF-Related Apoptosis-Inducing Ligand Tumor Necrosis Factor-alpha (metabolism) fas Receptor (metabolism, pharmacology)

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