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Chronic high dose L-dopa treatment does not alter the levels of dopamine D-1, D-2 or D-3 receptor in the striatum of normal monkeys: an autoradiographic study.

Abstract
To assess the role of dopamine receptors in the genesis of dyskinesia, we have used quantitative autoradiography to determine the effect of chronic L-dopa administration on dopamine D-1 (using [3H]SCH 23390), D-2 (using [3H]spiperone) and D-3 (using [3H]7-OH-DPAT) receptor binding levels in the striatum of dyskinetic or non-dyskinetic monkeys. Total and subregional striatal analysis showed no difference in D-1, D-2 or D-3 receptor binding in the caudate and putamen between monkeys receiving high dose L-dopa treatment with marked dyskinesia and those without dyskinesia compared to untreated animals. It thus appears unlikely that changes in dopamine receptor expression are a primary cause of L-dopa induced dyskinesia. Rather, a functional dissociation of D-2 receptor coupling to co-expressed enkephalin/adenosine-2a receptor activity in the striato-GPe indirect pathway may be more important in the development or expression of L-dopa-induced involuntary movements.
AuthorsB Y Zeng, R K Pearce, G M MacKenzie, P Jenner
JournalJournal of neural transmission (Vienna, Austria : 1996) (J Neural Transm (Vienna)) Vol. 108 Issue 8-9 Pg. 925-41 ( 2001) ISSN: 0300-9564 [Print] Austria
PMID11716146 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Benzazepines
  • Dopamine Agents
  • Dopamine Antagonists
  • Receptor, Adenosine A2A
  • Receptors, Dopamine
  • Receptors, Purinergic P1
  • Levodopa
Topics
  • Animals
  • Benzazepines (pharmacology)
  • Dopamine Agents (pharmacology)
  • Dopamine Antagonists (pharmacology)
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Dyskinesia, Drug-Induced (metabolism, physiopathology)
  • Female
  • Levodopa (pharmacology)
  • Macaca fascicularis
  • Male
  • Neostriatum (drug effects, metabolism, physiopathology)
  • Neurons (drug effects, metabolism)
  • Radioligand Assay
  • Receptor, Adenosine A2A
  • Receptors, Dopamine (drug effects, metabolism)
  • Receptors, Purinergic P1 (drug effects, metabolism)

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