[The preparation phosprenyl suppresses diarrhea and cattle infectious rhinotracheitis virus multiplication in sensitive cell cultures].

Abstract

Fosprenil suppressed the multiplication of cattle diarrhea virus in calf coronary vessel cell culture. Added to the culture of infected cells in a dose of 200 mg, the drug decreased the virus titer 30-fold in comparison with infected control cultures. Antiviral activity of fosprenil towards infective rhinotracheitis virus multiplication was still higher: in a dose of 100 mg it decreased the virus titer in fetal calf lung culture 100-fold in comparison with the control. Moreover, the cytopathogenic effects of the viruses in infected cultures were 24-48 h delayed under the effect of fosprenil in comparison with infected control cultures. These results recommend fosprenil for the treatment of cattle viral diseases.

• Authors: S V Ozherelkov, R V Belousova, L L Danilov, A V Deeva, S D Mal'tsev, A N Narovlianskiĭ, A V Sanin, A V Pronin
• Journal: Voprosy virusologii (Vopr Virusol) 2001 Sep-Oct Vol. 46 Issue 5 Pg. 43-5 ISSN: 0507-4088 [Print] Russia (Federation)
• Vernacular Title: Preparat fosprenyl podavliaet razmnozhenie virusov diarei i infektsionnogo rinotrakheita krupnogo rogatogo skota v chuvstvitel'nykh kul'turakh kletok.
• PMID: 11715710 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antiviral Agents
• Polyisoprenyl Phosphates
• phosprenyl

Topics

• Animals
• Antiviral Agents (pharmacology)
• Cattle
• Cells, Cultured
• Cytopathogenic Effect, Viral (drug effects)
• Diarrhea Viruses, Bovine Viral (drug effects, pathogenicity)
• Herpesvirus 1, Bovine (drug effects, pathogenicity)
• Infectious Bovine Rhinotracheitis (virology)
• Polyisoprenyl Phosphates (pharmacology)