[Antiviral activity of 2'-deoxy-2'-fluoroguanosine against influenza and herpes simplex viruses in cultured cells].

Abstract

High antiviral activity of 2'-deoxy-2'fluoroguanosine (2'-D-2'-FG) was observed in chicken embryo cells infected with FPV/Rostock/34 (H7N1) influenza virus and herpes simplex virus (HSV) type I (strain 1C). 50% inhibitory concentration (IC50) of 2'-D-2'-FG was 1.44 microM for FPV and 0.093 microM for HSV. IC50 of remantadine hydrochloride, ribavirin (FPV), and acycloguanosine (HSV) were < 0.46, 14.4, and 0.08 microM, respectively. Anti-HSV activity was confirmed in Vero cells: IC50 < 0.34 microM for 2'-D-2'-FG and IC50 < 0.044 microM for acycloguanosine.

• Authors: I Boreko, N I Pavlova, G V Zaĭtseva, I A Mikhaĭlopulo
• Journal: Voprosy virusologii (Vopr Virusol) 2001 Sep-Oct Vol. 46 Issue 5 Pg. 40-2 ISSN: 0507-4088 [Print] Russia (Federation)
• Vernacular Title: Protivovirusnaia aktivnost' 2'-dezoksi-2'-ftorguanozina v otnoshenii virusov grippa i prostogo gerpesa v kul'turakh kletok.
• PMID: 11715709 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• 2'-deoxy-2'-fluoroguanosine
• Deoxyguanosine

Topics

• Animals
• Antiviral Agents (pharmacology)
• Chick Embryo
• Chlorocebus aethiops
• Deoxyguanosine (analogs & derivatives, pharmacology)
• Herpesvirus 1, Human (drug effects)
• Microbial Sensitivity Tests
• Orthomyxoviridae (drug effects)
• Vero Cells