[Sigmoid colon cancer with multiple liver metastasis (H3) effectively treated with CPT-11 and DSM (degradable starch microsphere) HAI therapy and intensive high dosage 5-FU HAI therapy--a case report].

Abstract

A weekly HAI therapy (CPT-11 80 mg, MMC 4 mg, degradable starch microsphere (DSM) 600 mg) was given to a patient with sigmoid colon cancer and multiple liver metastasis (H3) who had been taking tegafur 300 mg/day and 5-FU 750 mg HAI/week, which resulted in PD. This therapy was carried out on an outpatient basis with minimum side effects (< grade 2). After 8 weeks, the tumor marker dropped to one tenth and the liver metastasis decreased in size (PR). The time courses of the concentrations of CPT-11, SN-38 and SN-38G were determined by drawing blood after HAI with or without DSM. The Cmax and AUC inf. of SN-38 at HAI without DSM were 17 ng/ml and 90.55 ng/h/ml, respectively, which was comparable to that at i.v. administration. The Cmax and AUC inf. of SN-38 at HAI with DSM were 12 ng/ml and 129.19 ng/h/ml, respectively, implying that DSM might have an enhancing effect on CPT-11 due to stasis of the hepatic artery that slows the conversion of CPT-11 to SN-38 resulting in a longer existence of SN-38.

• Authors: M Yukawa, H Ishikawa, T Nakayama, S Oshima, Y Katsumoto, J Furukawa, F Sue, M Inoue
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 28 Issue 11 Pg. 1763-7 (Oct 2001) ISSN: 0385-0684 [Print] Japan
• PMID: 11708029 (Publication Type: Case Reports, Journal Article)

Chemical References

• degradable starch microspheres
• Irinotecan
• Starch
• Fluorouracil
• Camptothecin

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Camptothecin (administration & dosage, analogs & derivatives, blood)
• Drug Administration Schedule
• Female
• Fluorouracil (administration & dosage)
• Humans
• Infusions, Intra-Arterial
• Irinotecan
• Liver Neoplasms (drug therapy, secondary)
• Middle Aged
• Sigmoid Neoplasms (pathology)
• Starch (administration & dosage)