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The importance of kinin antagonist treatment timing in closed head trauma.

AbstractBACKGROUND:
Giving LF 16-0687 Ms (a bradykinin B2 receptor antagonist) 1 hour after closed head trauma (CHT) previously was reported to decrease brain edema at 24 hours and improve neurologic severity score (NSS) at 7 days. It is not certain whether a greater benefit could be achieved by treatment sooner after CHT.
METHODS:
To examine the latter possibility we studied a surrogate condition for the earliest possible administration of LF 16-0687 Ms after CHT, e.g., we examined brain edema and NSS when LF 16-0687 Ms was given 15 min before CHT in rats.
RESULTS:
LF 16-0687 Ms decreased brain water content (80.0 +/- 1.4%, mean +/- SD) at 24 hours and improved NSS (2 +/- 3, median +/- range) at 7 days after CHT in comparison to that with CHT + saline (82.9 +/- 1.3% and 8 +/- 4).
CONCLUSION:
Similarity of the present results to those previously reported indicates that the benefit of giving LF 16-0687 Ms 1 hour after CHT appears to represent the maximal benefit afforded by this drug.
AuthorsM Rachinsky, D Pruneau, A A Artru, V Kapuler, A Alonchin, Y Smolanezki, Y Shapira
JournalThe Journal of trauma (J Trauma) Vol. 51 Issue 5 Pg. 944-8 (Nov 2001) ISSN: 0022-5282 [Print] United States
PMID11706345 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Bradykinin Receptor Antagonists
  • LF 16-0687
  • Quinolines
  • Receptor, Bradykinin B2
Topics
  • Analysis of Variance
  • Animals
  • Blood Pressure (drug effects)
  • Bradykinin Receptor Antagonists
  • Brain Edema (drug therapy, physiopathology)
  • Head Injuries, Closed (drug therapy, physiopathology)
  • Quinolines (administration & dosage, pharmacology)
  • Rats
  • Rats, Sprague-Dawley
  • Receptor, Bradykinin B2
  • Statistics, Nonparametric
  • Time Factors

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