Abstract | BACKGROUND: METHODS: To examine the latter possibility we studied a surrogate condition for the earliest possible administration of LF 16-0687 Ms after CHT, e.g., we examined brain edema and NSS when LF 16-0687 Ms was given 15 min before CHT in rats. RESULTS:
LF 16-0687 Ms decreased brain water content (80.0 +/- 1.4%, mean +/- SD) at 24 hours and improved NSS (2 +/- 3, median +/- range) at 7 days after CHT in comparison to that with CHT + saline (82.9 +/- 1.3% and 8 +/- 4). CONCLUSION: Similarity of the present results to those previously reported indicates that the benefit of giving LF 16-0687 Ms 1 hour after CHT appears to represent the maximal benefit afforded by this drug.
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Authors | M Rachinsky, D Pruneau, A A Artru, V Kapuler, A Alonchin, Y Smolanezki, Y Shapira |
Journal | The Journal of trauma
(J Trauma)
Vol. 51
Issue 5
Pg. 944-8
(Nov 2001)
ISSN: 0022-5282 [Print] United States |
PMID | 11706345
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bradykinin Receptor Antagonists
- LF 16-0687
- Quinolines
- Receptor, Bradykinin B2
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Topics |
- Analysis of Variance
- Animals
- Blood Pressure
(drug effects)
- Bradykinin Receptor Antagonists
- Brain Edema
(drug therapy, physiopathology)
- Head Injuries, Closed
(drug therapy, physiopathology)
- Quinolines
(administration & dosage, pharmacology)
- Rats
- Rats, Sprague-Dawley
- Receptor, Bradykinin B2
- Statistics, Nonparametric
- Time Factors
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