Expression of insulin-like growth factor-I (IGF-I) in aneurysmal bone cyst.

Abstract

The effects of insulin-like growth factor-I on bone tissue and its role in bone development have been extensively investigated, but there is little information on its role in the pathogenesis of aneurysmal bone cyst. Therefore, using the techniques of immunohistochemistry and in situ hybridization, the authors studied the expression of insulin-like growth factor-I in 19 specimens of aneurysmal bone cyst. Insulin-like growth factor-I or specific mRNA sequences encoding for insulin-like growth factor-I were detectable in all specimens tested and were mainly localized in multinucleate giant cells. In contrast, only insignificant levels of insulin-like growth factor-I expression were detectable in normal human bone tissue. Taken together with the previously reported role of insulin-like growth factor-I in the pathogenesis of giant cell tumor, the findings of this study suggest that insulin-like growth factor-I may play a role in the pathogenesis of aneurysmal bone cyst.

• Authors: A Leithner, S Lang, R Windhager, K Leithner, H Karlic, R Kotz, O A Haas
• Journal: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc (Mod Pathol) Vol. 14 Issue 11 Pg. 1100-4 (Nov 2001) ISSN: 0893-3952 [Print] United States
• PMID: 11706070 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• RNA, Messenger
• Insulin-Like Growth Factor I

Topics

• Adolescent
• Adult
• Bone Cysts, Aneurysmal (genetics, metabolism, pathology)
• Child
• Female
• Gene Expression
• Humans
• Immunohistochemistry
• In Situ Hybridization
• Insulin-Like Growth Factor I (analysis, genetics)
• Male
• Middle Aged
• RNA, Messenger (genetics, metabolism)