Long-term changes in collagen formation expressed by serum carboxyterminal propeptide of type-I procollagen and relation to left ventricular function after acute myocardial infarction.

Abstract	The purpose of this study was to investigate the long-term sequential changes in serum levels of the carboxyterminal propeptide of type-I procollagen (s-PICP), which is a marker of type-I collagen synthesis, and to assess its clinical value in relation to left ventricular (LV) function and prognosis following acute myocardial infarction (AMI). Forty-eight consecutive patients with their first AMI and 15 control subjects were studied. Patients with AMI were stratified according to the changes in s-PICP levels between days 1 and 90 (DeltaPICP) and divided into group I with < or =16.0 microg/l or group II with >16.0 microg/l. Patients in group II were characterized by LV dilatation, no improvement in ejection fraction and development of impaired diastolic filling from day 1 to 360, findings which were in contrast to group I. Cox regression analysis identified changes in s-PICP of >16.0 microg/l as an independent predictor of cardiac death or heart failure during follow-up. In conclusion, DeltaPICP relates to long-term changes in LV function and size, and provides prognostic information following AMI.
Authors	S H Poulsen, N B Høst, K Egstrup
Journal	Cardiology (Cardiology) Vol. 96 Issue 1 Pg. 45-50 ( 2001) ISSN: 0008-6312 [Print] Switzerland
PMID	11701940 (Publication Type: Comparative Study, Journal Article)
Copyright	Copyright 2001 S. Karger AG, Basel
Chemical References	Angiotensin-Converting Enzyme Inhibitors Collagen Type I Peptide Fragments Procollagen Collagen
Topics	Adult Aged Angiotensin-Converting Enzyme Inhibitors (therapeutic use) Blood Pressure (drug effects, physiology) Collagen (biosynthesis) Collagen Type I (blood, drug effects) Echocardiography, Doppler Female Follow-Up Studies Humans Male Middle Aged Myocardial Infarction (blood, diagnosis, drug therapy) Patient Readmission Peptide Fragments (blood) Predictive Value of Tests Procollagen (blood, drug effects) Prognosis Prospective Studies Regression Analysis Time Treatment Outcome Ventricular Function, Left (drug effects, physiology)

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