Intracerebral infusion of a second-generation ciliary neurotrophic factor reduces neuronal loss in rat striatum following experimental intracerebral hemorrhage.

Abstract	Neuronal and glial cell death in the striatum of a rat model of collagenase-induced intracerebral hemorrhage begins at 1 day and continues for at least 3 weeks. We hypothesized that administration of a neurotrophic agent would reduce neuronal loss in this experimental model. Because it has been shown to protect striatal neurons against excitotoxic injury, a second-generation ciliary neurotrophic factor (CNTF) (AXOKINE) was administered by continuous intracerebral infusion (2 microg/day) beginning 28 h after hemorrhage and continuing for 2 weeks. Magnetic resonance imaging showed that the hematoma size was comparable in control and treated rats prior to treatment. Counts of medium-sized striatal neurons within 320 microm of the hematoma 8 weeks after the hemorrhage revealed a slight but statistically significant benefit with a 42.5% loss in treated rats compared to 51.7% loss in controls. The results suggest that AXOKINE might be protective of striatal neurons in the vicinity of a hemorrhagic lesion.
Authors	M R Del Bigio, H J Yan, M Xue
Journal	Journal of the neurological sciences (J Neurol Sci) Vol. 192 Issue 1-2 Pg. 53-9 (Nov 15 2001) ISSN: 0022-510X [Print] Netherlands
PMID	11701153 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Ciliary Neurotrophic Factor Nerve Tissue Proteins Neuroprotective Agents Recombinant Proteins axokine
Topics	Animals Basal Ganglia Hemorrhage (drug therapy, pathology, physiopathology) Cell Death (drug effects, physiology) Cell Survival (drug effects, physiology) Cerebral Hemorrhage (drug therapy, pathology, physiopathology) Ciliary Neurotrophic Factor (pharmacology) Corpus Striatum (drug effects, pathology, physiopathology) Disease Models, Animal In Situ Nick-End Labeling Male Necrosis Nerve Degeneration (drug therapy, pathology, physiopathology) Nerve Tissue Proteins (pharmacology) Neuroglia (drug effects, metabolism, pathology) Neurons (drug effects, metabolism, pathology) Neuroprotective Agents (pharmacology) Rats Rats, Sprague-Dawley Recombinant Proteins (pharmacology) Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!