Abstract | BACKGROUND: METHODS: RESULTS: T groups showed normal oral glucose tolerance tests and metabolic parameters. The latter were altered in all D groups (P<0.005 to P<0.0001 versus N and T groups). AGEs were increased in the D groups (P<0.05 to P<0.001) versus the N groups. AGEs in the TA and TB groups were not different from those of the N groups but were significantly reduced (P<0.05 to P<0.001) when compared with those of the D groups. In the TC group, eye lens AGEs were significantly elevated (P<0.001) or significantly reduced (P<0.01) when compared with those of the N or D groups, respectively. Aortic collagen AGEs were elevated (P<0.01) by comparison with those of the N groups and not statistically different from those of the D groups. Tail tendon collagen AGE levels lay between those of the N and D groups, without reaching a statistical significance. CONCLUSIONS: These results indicate that primary and early secondary (groups TA and TB) but not late secondary (group TC) islet transplantations are capable of blocking or reducing an abnormal accumulation of AGEs, thus confirming the importance of preventive transplantation therapies.
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Authors | M Sensi, S Morano, E Sagratella, P Castaldo, S Morelli, M Vetri, V Caltabiano, F Purrello, D Andreani, E Vecci, U Di Mario |
Journal | Transplantation
(Transplantation)
Vol. 72
Issue 8
Pg. 1370-5
(Oct 27 2001)
ISSN: 0041-1337 [Print] United States |
PMID | 11685105
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Glycation End Products, Advanced
- Streptozocin
- Collagen
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Topics |
- Animals
- Aorta
(chemistry)
- Collagen
(analysis)
- Diabetes Mellitus, Experimental
(metabolism, therapy)
- Glycation End Products, Advanced
(analysis)
- Islets of Langerhans Transplantation
- Lens, Crystalline
(chemistry)
- Male
- Rats
- Rats, Inbred Lew
- Streptozocin
- Tail
- Tendons
(chemistry)
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