Alzheimer II astrocytosis following methionine sulfoximine.

Abstract

A light microscopic study was performed during the preictal period following the administration of methionine sulfoximine (MSO) to adult rats. The principal morphologic observation was the development of Alzheimer II astrocytes in gray matter, suggesting that the metabolic abnormality induced by MSO is initially confined to the astrocyte. In view of the association of the Aizheimer II astrocyte with hyperammonemic states, the drug toxicity may be secondary to the presence of ammonia. A possible mechanism involves astrocytes in the development of seizures produced by MSO.

• Authors: J A Gutierrez, M D Norenberg
• Journal: Archives of neurology (Arch Neurol) Vol. 32 Issue 2 Pg. 123-6 (Feb 1975) ISSN: 0003-9942 [Print] United States
• PMID: 1168449 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Methionine Sulfoximine

Topics

• Alzheimer Disease (chemically induced, pathology)
• Animals
• Astrocytes (ultrastructure)
• Cell Count
• Cell Nucleus (ultrastructure)
• Cerebral Cortex (pathology)
• Dementia (chemically induced)
• Humans
• Male
• Methionine Sulfoximine (poisoning)
• Neuroglia (ultrastructure)
• Rats
• Seizures (chemically induced)