Abstract |
Despite an increase in the number of patients treated for hypertension, blood pressure control is achieved in a minority of patients. The use of rational, well-tolerated combination regimens with complementary modes of action, such as an AT1-receptor blocker administered with a low dose of a thiazide diuretic, provides an effective and well-tolerated management strategy for patients who require more than monotherapy to control blood pressure. In clinical trials in patients with mild-to-moderate hypertension, a newly available combination of candesartan cilexetil- hydrochlorothiazide (HCT) 16/12.5 mg was significantly more effective than either monotherapy. This combination was also more effective than losartan-HCT 50/12.5 mg in two double-blind, randomized studies in patients with mild, moderate or severe hypertension. Furthermore, the antihypertensive efficacy of candesartan cilexetil-HCT was evident at up to 48 h following the last dose, while the effect of losartan-HCT declined rapidly during this period. Thus, the new fixed-dose AT1-receptor blocker/ diuretic combination, candesartan cilexetil-HCT 16/12.5 mg combines enhanced efficacy with excellent tolerability and sets a new standard for the treatment of hypertension requiring more than monotherapy.
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Authors | P Trenkwalder |
Journal | Blood pressure. Supplement
(Blood Press Suppl)
Issue 3
Pg. 18-25
( 2001)
ISSN: 0803-8023 [Print] Sweden |
PMID | 11683473
(Publication Type: Journal Article, Review)
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Chemical References |
- Angiotensin Receptor Antagonists
- Antihypertensive Agents
- Benzothiadiazines
- Diuretics
- Receptor, Angiotensin, Type 1
- Sodium Chloride Symporter Inhibitors
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Topics |
- Angiotensin Receptor Antagonists
- Antihypertensive Agents
(administration & dosage, adverse effects, therapeutic use)
- Benzothiadiazines
- Diuretics
- Drug Interactions
- Drug Therapy, Combination
- Humans
- Hypertension
(drug therapy)
- Receptor, Angiotensin, Type 1
- Sodium Chloride Symporter Inhibitors
(administration & dosage, adverse effects, therapeutic use)
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