Abstract | BACKGROUND: The genetic background of atopic eczema might be heterogeneous and there is a possibility that immunoglobulin (Ig)E responsiveness in patients with atopic eczema is controlled separately from the development of atopic eczema. Although both interleukin (IL)-4 and the IL-4 receptor alpha chain have an important role for IgE production and are therefore possible candidate genes for atopy, it has not been clarified whether these genes play any roles in atopic eczema patients who have normal IgE productivity. OBJECTIVE: We aimed to assess whether the polymorphisms of the IL-4 gene and the IL-4 receptor alpha chain gene play any roles in atopic eczema patients, particularly in patients who have normal IgE productivity. METHOD: We determined the genotype with regard to polymorphisms in the genes for IL-4 and the IL-4 receptor alpha chain (- 589C/T of IL-4; Ile50Val, Ala375Glu and Arg551Gln of IL-4 receptor alpha chain) in patients with atopic eczema using the fluorogenic 5' nuclease assay. RESULTS: CONCLUSION: These results suggest that the polymorphisms in the IL-4 gene and the IL-4 receptor alpha chain gene play no role in the development of atopic eczema in patients who have normal IgE productivity.
|
Authors | K Tanaka, H Sugiura, M Uehara, Y Hashimoto, C Donnelly, D S Montgomery |
Journal | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
(Clin Exp Allergy)
Vol. 31
Issue 10
Pg. 1522-7
(Oct 2001)
ISSN: 0954-7894 [Print] England |
PMID | 11678851
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Receptors, Interleukin-4
- Interleukin-4
- Immunoglobulin E
|
Topics |
- Adolescent
- Adult
- Dermatitis, Atopic
(genetics, immunology)
- Female
- Gene Frequency
(genetics)
- Genetic Heterogeneity
- Genetic Variation
(genetics)
- Genotype
- Humans
- Immunoglobulin E
(biosynthesis, blood)
- Interleukin-4
(genetics)
- Japan
(epidemiology)
- Male
- Middle Aged
- Receptors, Interleukin-4
(genetics)
|