Aggressive NK cell lymphoma/leukemia with clonal der(3)t(1;3) (q12;p25), del(6)(q13) and del(13)(q12q14).

Abstract

We describe a 54-year-old man with CD2, CD7, and CD56-positive but CD3, CD4, and CD8-negative aggressive NK cell lymphoma/leukemia. Chromosome analysis of the peripheral blood cells showed clonal aberration consisting of 46,XY,dup(3)(p21p25),der(3)t(1;3)(q12;p25),del(5)(q13q22), del(6)(q13),del(13)(q12q14). The peripheral blood lymphoma cells contained clonal EBV-DNA by Southern blot analysis. The disease was refractory to chemotherapy and the clinical course was aggressive and rapid. Deletion 6q and deletion 13q have been frequently reported in NK cell lymphoma/leukemia. Thus, some tumor suppressor genes involving NK cell malignancies may be present in these regions.

• Authors: H Hamaguchi, M Yamaguchi, K Nagata, E Koike, M Imagunbai, Y Tsurukubo, K Yamamoto
• Journal: Cancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 130 Issue 2 Pg. 150-4 (Oct 15 2001) ISSN: 0165-4608 [Print] United States
• PMID: 11675136 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antigens, CD7
• CBX5 protein, human
• CD2 Antigens
• CD3 Complex
• CD4 Antigens
• CD56 Antigen
• CD8 Antigens
• Chromobox Protein Homolog 5

Topics

• Antigens, CD7 (biosynthesis)
• Blotting, Southern
• CD2 Antigens (biosynthesis)
• CD3 Complex (biosynthesis)
• CD4 Antigens (biosynthesis)
• CD56 Antigen (biosynthesis)
• CD8 Antigens (biosynthesis)
• Chromobox Protein Homolog 5
• Chromosome Aberrations
• Chromosome Deletion
• Chromosomes, Human, Pair 13
• Chromosomes, Human, Pair 3
• Chromosomes, Human, Pair 6
• Gene Deletion
• Gene Duplication
• Herpesvirus 4, Human (genetics)
• Humans
• In Situ Hybridization, Fluorescence
• Killer Cells, Natural (cytology)
• Leukemia (genetics)
• Lymphoma (genetics)
• Male
• Middle Aged