Abstract |
The aim of this study was to demonstrate whether total triterpenic fraction of Centella asiatica ( TTFCA), was effective in improving the microcirculation in venous hypertension and microangiopathy. Forty patients with severe venous hypertension, ankle swelling, lipodermatosclerosis were included. After informed consent, patients were randomized into a treatment and a placebo group: those in the treatment group received TTFCA ( tablets, 60 mg, twice daily for 8 weeks). The two groups of subjects were comparable for age and sex distribution. The mean age was 48 years (SD 9; M:F= 11:11) in the treatment group (22 patients) and 47.6 (SD 7; M:F= 10:8) in the placebo group (18 patients). There were no differences between placebo and treatment group at inclusion; there was no change between inclusion and measurements at 8 weeks in the placebo group. A decrease (p < 0.05) in RF (flux at rest) and RAS (rate of ankle swelling) were observed in the treatment group. The decrease in capillary filtration was associated with improvement in signs and symptoms (p < 0.05). The difference in flux, signs and symptoms, and filtration was clinically important at 8 weeks. No side effects were observed. In conclusion venous microangiopathy was improved by TTFCA treatment.
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Authors | M R Cesarone, G Belcaro, M T De Sanctis, L Incandela, M Cacchio, P Bavera, E Ippolito, M Bucci, M Griffin, G Geroulakos, M Dugall, S Buccella, S Kleyweght, M Cacchio |
Journal | Angiology
(Angiology)
Vol. 52 Suppl 2
Pg. S15-18
(Oct 2001)
ISSN: 0003-3197 [Print] United States |
PMID | 11666117
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Plant Extracts
- TECA
- Triterpenes
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Topics |
- Administration, Oral
- Female
- Humans
- Hypertension
(complications, physiopathology)
- Male
- Microcirculation
- Middle Aged
- Plant Extracts
(therapeutic use)
- Prospective Studies
- Severity of Illness Index
- Triterpenes
(therapeutic use)
- Venous Insufficiency
(drug therapy, etiology, physiopathology)
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