Hemorrhage in the oculomotor nerve as a complication of leukemia.

Abstract

Oculomotor paralysis of a patient with leukemia was revealed at autopsy to be caused by a hemorrhage in the oculomotor nerve. In a 63-year-old woman with pre-B-cell acute lymphatic leukemia, leukemic invasions occurred in her spinal cord and right oculomotor nerve during a hematological remission state. The oculomotor palsy was aggravated to complete paralysis during a leukemic relapse, which lasted until her death. An autopsy revealed a hemorrhage along with leukemic cells in the right oculomotor nerve at the segment in the upper orbital fissure. Although hemorrhagic oculomotor paralysis is a very rare complication, reports of its occurrence will likely increase with improved survival times of leukemia patients due to advances in chemotherapy.

• Authors: K Jinnai, Y Hayashi
• Journal: Neuropathology : official journal of the Japanese Society of Neuropathology (Neuropathology) Vol. 21 Issue 3 Pg. 241-4 (Sep 2001) ISSN: 0919-6544 [Print] Australia
• PMID: 11666023 (Publication Type: Case Reports, Journal Article)

Chemical References

• HLA Antigens

Topics

• Acute Disease
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• B-Lymphocytes (metabolism, pathology)
• Cervical Vertebrae
• Female
• HLA Antigens (metabolism)
• Hemorrhage (etiology, pathology, physiopathology)
• Humans
• Immunohistochemistry
• Leukemic Infiltration (complications, pathology, physiopathology)
• Middle Aged
• Neoplasm Regression, Spontaneous
• Oculomotor Nerve (blood supply, pathology, physiopathology)
• Oculomotor Nerve Diseases (etiology, pathology, physiopathology)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (complications, pathology, physiopathology)
• Recurrence
• Spinal Cord (blood supply, pathology, physiopathology)
• Treatment Outcome