Anti-inflammatory and analgesic effect of herbal preparation: septilin.

Abstract

Septilin a proprietary herbal preparation has been reported to have wound healing and immunomodulatory properties. The present study was, therefore, designed to ascertain the anti-inflammatory and analgesic properties of septilin in rats and mice by oral route. Anti-inflammatory activity was assessed by using acute (carrageenan-induced paw oedema), sub-acute (cotton pellet granuloma) and chronic (Freund's adjuvant induced-arthritis) models of inflammation. Administration of septilin in a dose of 500 mg/kg orally produced significant anti-inflammatory effect in all experimental models of inflammation. However, the anti-inflammatory effect was more in chronic model when compared to reference standard drug (Prednisolone). Septilin (500 mg/kg) produced significant analgesic effect on tall flick test. However, the effect was less when compared to morphine (5 mg/kg) but when septilin was combined with subanalgesic dose of morphine (2.5 mg/kg) the analgesic effect was more than the either drug given alone. On GAA induced writhing test septilin produced significant analgesic effect at a dose of 750 mg/kg which was comparable to diclofenac (50 mg/kg). However, subanalgesic dose of septilin (500 mg/kg) when combined with diclofenac (25 mg/kg), analgesic effect was enhanced significantly.

• Authors: N Khanna, S B Sharma
• Journal: Indian journal of medical sciences (Indian J Med Sci) Vol. 55 Issue 4 Pg. 195-202 (Apr 2001) ISSN: 0019-5359 [Print] India
• PMID: 11665389 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Analgesics
• Anti-Inflammatory Agents, Non-Steroidal
• Plant Extracts
• septilin

Topics

• Analgesics (pharmacology)
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Inflammation (drug therapy)
• Male
• Mice
• Models, Animal
• Pain Measurement (drug effects)
• Phytotherapy
• Plant Extracts (pharmacology)
• Rats