A case of polymyositis with anti-histidyl-t-RNA synthetase (Jo-1) antibody syndrome following extensive vinyl chloride exposure.

Abstract

Occupational exposure to vinyl chloride monomers is known to induce Raynaud's phenomenon, periportal fibrosis, liver angiosarcoma and scleroderma-like syndrome. We report the first case of occupational polymyositis in a 58-year-old man exposed to vinyl chloride. A dysimmune process was strongly suspected as having induced vinyl chloride disease. Our patient had an anti-histidyl-t-RNA-synthetase (Jo1) antibody, which has never to our knowledge been reported in this occupational disease.

• Authors: J Serratrice, B Granel, X Pache, P Disdier, C De Roux-Serratrice, J F Pellissier, P J Weiller
• Journal: Clinical rheumatology (Clin Rheumatol) Vol. 20 Issue 5 Pg. 379-82 ( 2001) ISSN: 0770-3198 [Print] Germany
• PMID: 11642524 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Antinuclear
• Jo-1 antibody
• Vinyl Chloride

Topics

• Antibodies, Antinuclear (analysis, immunology)
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Occupational Diseases (chemically induced, immunology)
• Occupational Exposure (adverse effects)
• Polymyositis (chemically induced, diagnosis)
• Risk Assessment
• Syndrome
• Time Factors
• Vinyl Chloride (adverse effects)