Myelitis and ascending flaccid paralysis due to congenital toxoplasmosis.

Abstract

A 4-week-old female newborn developed ascending flaccid paralysis and radiologic evidence of myelitis; the diagnosis of congenital toxoplasmosis was confirmed by the presence of Toxoplasma gondii-specific immunoglobulins in both mother and infant, and detection of Toxoplasma sequences in the infant's cerebrospinal fluid by polymerase chain reaction analysis. Treatment with pyrimethamine, sulfadiazine, and methylprednisolone resulted in improvement.

• Authors: A L Campbell, J E Sullivan, G S Marshall
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 33 Issue 10 Pg. 1778-81 (Nov 15 2001) ISSN: 1058-4838 [Print] United States
• PMID: 11641828 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Animals
• Female
• Humans
• Infant, Newborn
• Muscle Hypotonia (diagnosis, etiology)
• Myelitis (diagnosis, etiology)
• Paralysis (diagnosis, etiology)
• Toxoplasma (isolation & purification)
• Toxoplasmosis, Congenital (complications)