Antitumor effect of 2-thio-4-hydrazinouracil on transplantable tumors.

Abstract

The cytostatic activity of 2-thio-4-hydrazinouracil (THU) on some transplantable tumors has been studied. A strong effect of this compound (between 60% and 100% suppression) has been found in the case of Myeloma P-8 (MOPC-21) and Sarcoma 180 (Crocker). A less pronounced effect has been observed on Yoshida sarcoma, while the development of Jensen sarcoma is not influenced.

• Authors: E V Golovinsky, E A Emanuilov, N C Spassovska, A V Spassov
• Journal: Neoplasma (Neoplasma) Vol. 22 Issue 3 Pg. 255-8 ( 1975) ISSN: 0028-2685 [Print] Slovakia
• PMID: 1161120 (Publication Type: Journal Article)

Chemical References

• 2-thio-4-hydrazinouracil
• Thiouracil

Topics

• Animals
• Drug Evaluation, Preclinical
• Injections, Intraperitoneal
• Male
• Mice
• Neoplasm Transplantation
• Neoplasms, Experimental (drug therapy)
• Plasmacytoma (drug therapy)
• Rats
• Sarcoma 180 (drug therapy)
• Sarcoma, Experimental (drug therapy)
• Sarcoma, Yoshida (drug therapy)
• Thiouracil (analogs & derivatives, therapeutic use, toxicity)