Probucol decreases total body fat loss in VX2-carcinoma-induced cachectic rabbits.

Abstract

We previously reported the continuous decrease of total body fat in VX2-carcinoma-bearing rabbits after tumor implantation, as well as changes in the serum lipid profile. Probucol, an antioxidant drug, has a cholesterol lowering effect against hyperlipidemic subjects. VX2-carcinoma-bearing rabbits fed with a diet containing 1% probucol did not show any difference in serum lipid compositions as compared with rabbits fed with a control diet. Similarly serum lipolytic activity showed no differences, whether probucol was administered or not, while the decrease in total body fat was significantly less when probucol was administered.

• Authors: Y Hyun, O Ishiko, K Honda, K Hirai, T Sumi, K Hattori, E Nakagawa, T Yasui, S Nishimura, S Ogita
• Journal: Oncology reports (Oncol Rep) 2001 Nov-Dec Vol. 8 Issue 6 Pg. 1309-11 ISSN: 1021-335X [Print] Greece
• PMID: 11605055 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticholesteremic Agents
• Antioxidants
• Lipids
• Probucol

Topics

• Adipose Tissue (drug effects, metabolism)
• Animals
• Anticholesteremic Agents (pharmacology)
• Antioxidants (pharmacology)
• Cachexia (etiology, metabolism)
• Lipids (blood)
• Male
• Neoplasm Transplantation
• Neoplasms (physiopathology)
• Probucol (pharmacology)
• Rabbits