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Immunohistochemical expression analysis of inhibin-alpha and -beta subunits in partial and complete moles, trophoblastic tumors, and endometrial decidua.

Abstract
The expression of inhibin-alpha subunit has been described in normal placentas, hydatidiform moles, and trophoblastic tumors. We performed a double immunohistochemical expression analysis of inhibin-alpha and inhibin-beta subunits in a cytogenetically well characterized series of 21 complete and 22 partial hydatidiform moles, 2 placental site trophoblastic tumors, and one choriocarcinoma. Syncytiotrophoblastic cells were consistently inhibin-alpha and inhibin-beta positive in all hydatidiform moles and in the one choriocarcinoma. Cytotrophoblast was negative for both subunits in all trophoblastic lesions studied. While villous intermediate trophoblastic cells were consistently inhibin-alpha negative in all hydatidiform moles, focal inhibin-beta immunoreactivity was detected in villous intermediate trophoblast in approximately one third of complete and partial hydatidiform moles. Decidual stromal cells in 40 hydatidiform moles were inhibin-alpha and inhibin-beta positive in approximately one third of cases. Both placental site trophoblastic tumors were inhibin-alpha positive but inhibin-beta negative. Our findings indicate that inhibin-alpha and -beta subunits are consistently coexpressed in syncytiotrophoblast in complete and partial moles. Immunohistochemical detection of inhibin subunits may be useful in the differential diagnosis of trophoblastic lesions.
AuthorsF Kommoss, D Schmidt, W Coerdt, J Olert, H Müntefering
JournalInternational journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists (Int J Gynecol Pathol) Vol. 20 Issue 4 Pg. 380-5 (Oct 2001) ISSN: 0277-1691 [Print] United States
PMID11603223 (Publication Type: Journal Article)
Chemical References
  • inhibin-alpha subunit
  • Inhibins
  • Inhibin-beta Subunits
Topics
  • Choriocarcinoma (chemistry)
  • Decidua (chemistry)
  • Female
  • Humans
  • Hydatidiform Mole (genetics, metabolism)
  • Immunohistochemistry
  • Inhibin-beta Subunits (analysis)
  • Inhibins (analysis)
  • Karyotyping
  • Pregnancy
  • Stromal Cells (chemistry)
  • Trophoblastic Neoplasms (chemistry)
  • Uterine Neoplasms (chemistry)

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