Abstract | OBJECTIVE: METHODS: The rat model was made by 5-hour restraint water-immersion stress and two intraperitoneal injections of cerulein (40 micrograms/kg) at hourly interval. BQ123 (3 or 6 mg/kg) was administered intravenously 30 minutes before and 2 hours after the first cerulein injection. RESULTS:
Acute hemorrhagic pancreatitis was induced in all rats treated with cerulin + stress. The score for pancreatic hemorrhage was 2.4 +/- 0.2 in this group. In the rats pretreated with BQ123, the score was reduced to 1.0 +/- 0.0, pancreas wet weight and serum amylase activity were significantly reduced, and histologic alterations in the pancreas lightened, also the local pancreatic blood flow improved without affecting the systemic blood pressure. CONCLUSIONS:
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Authors | X Liu, I Nakano, T Ito, T Kimura, H Nawata |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 112
Issue 7
Pg. 603-7
(Jul 1999)
ISSN: 0366-6999 [Print] China |
PMID | 11601252
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Endothelin Receptor Antagonists
- Endothelin-1
- Peptides, Cyclic
- Ceruletide
- cyclo(Trp-Asp-Pro-Val-Leu)
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Topics |
- Acute Disease
- Animals
- Ceruletide
- Endothelin Receptor Antagonists
- Endothelin-1
(metabolism)
- Male
- Pancreatitis
(chemically induced, metabolism)
- Peptides, Cyclic
(pharmacology)
- Rats
- Rats, Sprague-Dawley
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