[The significance of antiendothelial cell antibodies in patients with lupus nephritis: a clinical and renal pathological study].

Abstract

OBJECTIVE:

To investigate the prevalence and possible role of antiendothelial cell antibodies (AECA) in the pathogenesis of lupus nephritis.

METHODS:

Sera from 58 patients with lupus nephritis were studied. Cellular ELISA were used to detect AECA, and immunoblotting was performed to determine specific endothelial target.

RESULTS:

36% of the patients with lupus nephritis had elevated IgG-AECA. IgG-AECA was correlated with the higher incidence of thrombocytopenia, higher serum immuoglobulin G levels, lower serum C3(13 +/- 7) g/L and higher titers of antibodies against nucli and dsDNA. AECA consisted of a group of heterogeneous antibodies and reacted with different endothelial cell antigens ranging from 12,000 to 90,000 in molecular size. A correlation was demonstrated between heavy proteinuria (> 3.5 g/24 hr) and the existence of antibodies simultaneously against the 27,000, 29,000 endothelial cell antigens (34% vs 4%), we also found an association between the presence of glomerular capillary thrombi and antibody against the 29,000 endothelial cell antigen (60% vs 14%).

CONCLUSION:

These results suggested that lupus nephritis patients with AECA showed a complex autoimmune disorder and provided an indirect evidence that AECA might contribute to the pathogenesis of lupus nephritis.

• Authors: H Geng, Y Zhang, M Zhao
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 79 Issue 1 Pg. 31-3 (Jan 1999) ISSN: 0376-2491 [Print] China
• PMID: 11601003 (Publication Type: English Abstract, Journal Article)

Chemical References

• Autoantibodies
• Biomarkers
• Immunoglobulin G
• anti-endothelial cell antibody

Topics

• Adult
• Autoantibodies (blood)
• Biomarkers
• Biopsy, Needle
• Female
• Humans
• Immunoglobulin G (blood)
• Kidney (pathology)
• Lupus Nephritis (immunology, pathology)
• Male