T-cell responses to viral, bacterial and protozoan antigens in rheumatoid inflammation. Selective migration of T cells to synovial tissue.

To identify any preferential or selective migration of T-cell specificities to inflamed tissues of rheumatoid arthritis (RA) patients.
Lymphocytes from peripheral blood (PB) and synovial tissue (ST) were isolated from RA patients and stimulated with a panel of crude antigen preparations from 18 bacterial, protozoan and viral sources. Proliferative responses of the T lymphocytes to each antigen and group of antigens were compared in PB and ST. Antigen-specific T-cell clones were developed and their migratory capacities towards synovial chemokines were compared.
ST-derived T cells showed a small but significantly higher stimulation index (SI) to the group of intestinal bacteria compared with PB T cells. Conversely, responses of ST-derived T cells to Acanthamoeba polyphaga (AP) were both profoundly and significantly lower compared with PB-derived T cells. The viral antigens as a whole gave comparable reactivities in blood and ST. The migratory capacity of AP-specific T-cell clones towards chemokines produced by ST was profoundly poorer compared with Campylobacter jejuni- and herpes simplex virus-specific T-cell clones.
The results indicate a selective migration of T cells of given specificities to the inflamed rheumatoid synovium.
AuthorsK R Shadidi, T Aarvak, S Jeansson, J E Henriksen, J B Natvig, K M Thompson
JournalRheumatology (Oxford, England) (Rheumatology (Oxford)) Vol. 40 Issue 10 Pg. 1120-5 (Oct 2001) ISSN: 1462-0324 [Print] England
PMID11600741 (Publication Type: Journal Article)
Chemical References
  • Antigens, Bacterial
  • Antigens, Protozoan
  • Antigens, Viral
  • Acanthamoeba (immunology)
  • Adult
  • Aged
  • Amebiasis (immunology)
  • Animals
  • Antigens, Bacterial (immunology)
  • Antigens, Protozoan (immunology)
  • Antigens, Viral (immunology)
  • Arthritis, Rheumatoid (immunology)
  • Campylobacter Infections (immunology)
  • Campylobacter jejuni (immunology)
  • Cell Movement (immunology)
  • Female
  • Herpes Simplex (immunology)
  • Humans
  • Male
  • Middle Aged
  • Simplexvirus (immunology)
  • Synovial Membrane (cytology, immunology)
  • T-Lymphocytes (immunology)

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