Lobular carcinoma with cytoplasmic granules.

Abstract	We report on a case of invasive lobular carcinoma of the breast with a previously undescribed cytologic feature. Diff-Quik-stained cytologic preparations showed uniform single cells with prominent coarse cytoplasmic granules. Ultrastructurally, the granules showed features suggestive of autophagosomes and/or degenerative mitochondria. The cytologic differential diagnosis included granulocytic sarcoma, metastatic melanoma, extramedullary hematopoiesis, large granulocytic leukemia/lymphoma, and mast-cell tumor. Adjunctive studies were helpful in the diagnosis of carcinoma. Histologic study of the mastectomy specimen showed classic type of invasive lobular carcinoma.
Authors	A Vdovenko, R Bass, P Tauchi-Nishi, T Namiki
Journal	Diagnostic cytopathology (Diagn Cytopathol) Vol. 25 Issue 4 Pg. 253-7 (Oct 2001) ISSN: 8755-1039 [Print] United States
PMID	11599111 (Publication Type: Case Reports, Journal Article)
Copyright	Copyright 2001 Wiley-Liss, Inc.
Topics	Aged Biopsy, Needle Breast Neoplasms (chemistry, diagnosis, surgery, ultrastructure) Carcinoma, Lobular (chemistry, diagnosis, surgery, ultrastructure) Cytoplasmic Granules (pathology, ultrastructure) Diagnosis, Differential Female Flow Cytometry Humans Microscopy, Electron

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