QSAR of anticancer compounds. Bis(11-oxo-11H-indeno[1,2-b]quinoline-6-carboxamides), bis(phenazine-1-carboxamides), and bis(naphthalimides).

Abstract

QSAR have been developed for the anticancer activity (growth inhibition) of various tumor cells by bis(11-oxo-11H-indeno[1,2-b]quinoline-6-carboxamides), bis(phenazine-1-carboxamides), and bis(naphthalimides). Of the seven QSAR, positive hydrophobic interactions are found in only two examples: bis(naphthalimides) versus human colon cancer cells. This is consistent with other QSAR of anticancer compounds where hydrophobic interactions are found to be unimportant.

• Authors: S B Mekapati, W A Denny, A Kurup, C Hansch
• Journal: Bioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 9 Issue 11 Pg. 2757-62 (Nov 2001) ISSN: 0968-0896 [Print] England
• PMID: 11597455 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• 11-oxo-11H-indeno(1,2-b)quinolinecarboxamide
• Antineoplastic Agents
• Imides
• Indenes
• Phenazines
• Quinolines
• Quinolones
• phenazine-1-carboxamide
• 1-Naphthylamine

Topics

• 1-Naphthylamine (analogs & derivatives, chemistry)
• Animals
• Antineoplastic Agents (chemistry)
• Cell Division (drug effects)
• Dimerization
• Drug Screening Assays, Antitumor
• Humans
• Imides (chemistry)
• Indenes (chemistry)
• Inhibitory Concentration 50
• Mice
• Phenazines (chemistry)
• Quantitative Structure-Activity Relationship
• Quinolines (chemistry)
• Quinolones (chemistry)
• Tumor Cells, Cultured (drug effects)