Abstract | OBJECTIVE: To investigate the mechanism of PDGF-AB to promote wound healing and its role during the process of scar formation. METHODS: In vitro cultured fibroblasts of human normal skin and hypertrophic scar were treated with PDGF-AB. The expression of Pro alpha 1 (III) mRNA of the fibroblasts was evaluated by in situ hybridization technique. RESULTS: CONCLUSIONS:
PDGF-AB may promote wound healing by stimulating extracellular matrix synthesis, e.g. collagen. PDGF-AB may also play a role in scar formation through collagen deposition.
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Authors | M Dong, B Chen, M Xu |
Journal | Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery
(Zhonghua Zheng Xing Wai Ke Za Zhi)
Vol. 16
Issue 2
Pg. 78-80
(Mar 2000)
ISSN: 1009-4598 [Print] China |
PMID | 11593623
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Biomarkers
- Platelet-Derived Growth Factor
- Procollagen
- RNA, Messenger
- Recombinant Proteins
- platelet-derived growth factor AB
- Collagen
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Topics |
- Biomarkers
- Cicatrix
(metabolism)
- Cicatrix, Hypertrophic
(metabolism)
- Collagen
(biosynthesis)
- Fibroblasts
(metabolism)
- Humans
- Platelet-Derived Growth Factor
(pharmacology)
- Procollagen
(biosynthesis, genetics)
- RNA, Messenger
(biosynthesis, genetics)
- Recombinant Proteins
(pharmacology)
- Skin
(metabolism)
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