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[The effects of PDGF-AB on pro alpha 1 (III). mRNA expression of fibroblasts].

AbstractOBJECTIVE:
To investigate the mechanism of PDGF-AB to promote wound healing and its role during the process of scar formation.
METHODS:
In vitro cultured fibroblasts of human normal skin and hypertrophic scar were treated with PDGF-AB. The expression of Pro alpha 1 (III) mRNA of the fibroblasts was evaluated by in situ hybridization technique.
RESULTS:
PDGF-AB could increase Pro alpha 1 (III) mRNA expression of fibroblasts of both normal skin and hypertrophic scar in a dose-dependent manner. However, the effect of PDGF-AB on hypertrophic scar fibroblasts was stronger.
CONCLUSIONS:
PDGF-AB may promote wound healing by stimulating extracellular matrix synthesis, e.g. collagen. PDGF-AB may also play a role in scar formation through collagen deposition.
AuthorsM Dong, B Chen, M Xu
JournalZhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery (Zhonghua Zheng Xing Wai Ke Za Zhi) Vol. 16 Issue 2 Pg. 78-80 (Mar 2000) ISSN: 1009-4598 [Print] China
PMID11593623 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Biomarkers
  • Platelet-Derived Growth Factor
  • Procollagen
  • RNA, Messenger
  • Recombinant Proteins
  • platelet-derived growth factor AB
  • Collagen
Topics
  • Biomarkers
  • Cicatrix (metabolism)
  • Cicatrix, Hypertrophic (metabolism)
  • Collagen (biosynthesis)
  • Fibroblasts (metabolism)
  • Humans
  • Platelet-Derived Growth Factor (pharmacology)
  • Procollagen (biosynthesis, genetics)
  • RNA, Messenger (biosynthesis, genetics)
  • Recombinant Proteins (pharmacology)
  • Skin (metabolism)

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