The role of ICAM-1 molecule in the migration of Langerhans cells in the skin and regional lymph node.

Abstract

ICAM-1 (CD54) plays an important role in the cell-cell interaction and migration of leukocytes. Previous studies have shown that ICAM-1 is involved in inflammatory reactions and that a defect in ICAM-1 gene inhibits allergic contact hypersensitivity. This study indicates that the migration of hapten presenting Langerhans cells into the regional lymph nodes was significantly reduced in ICAM-1-deficient mice compared to wild-type C57BL/6 mice. The reduced number of dendritic cells in regional lymph nodes did not result from abnormal migration of Langerhans cells into the skin of ICAM-1-deficient mice. The concentration and distribution of Langerhans cells in the naïve skin of ICAM-1-deficient mice was equal to that of wild-type mice. Following hapten sensitization, Langerhans cell migration out of the skin and recruitment of fresh Langerhans cells back to the epidermis was not affected in ICAM-1-deficient mice. Further experiments demonstrated that ICAM-1 deficiency on lymphatic endothelium rather than on dendritic cells was responsible for the reduced migration of Langerhans cells into draining lymph nodes. This study indicates that ICAM-1 regulates the migration of dendritic cells into regional lymph nodes but not into or out of the skin.

• Authors: H Xu, H Guan, G Zu, D Bullard, J Hanson, M Slater, C A Elmets
• Journal: European journal of immunology (Eur J Immunol) Vol. 31 Issue 10 Pg. 3085-93 (Oct 2001) ISSN: 0014-2980 [Print] Germany
• PMID: 11592085 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Intercellular Adhesion Molecule-1

Topics

• Animals
• Cell Movement
• Dendritic Cells (physiology)
• Intercellular Adhesion Molecule-1 (physiology)
• Langerhans Cells (physiology)
• Lymph Nodes (immunology)
• Mice
• Mice, Inbred C57BL
• Skin (immunology)