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Topical application of vitamin A reverses metaplasia of rat vaginal epithelium: a rapid and efficient approach to improve mucosal barrier function.

Abstract
Retinyl palmitate and its metabolites retinol and retinoic acid control growth and epithelial differentiation. Systemic or local vitamin A deficiency induced by malnutrition, continuous chemical irritation or locally induced by inflammation causes squamous metaplastic changes in the epithelium of mucous membranes. We demonstrate that in an animal model topically applied retinyl palmitate can be taken up by the mucosal cells independently from the systemic supply. Under in vivo conditions metabolic changes in vaginal epithelium of rats were shown to be reversed by treatment with topical retinyl palmitate. - After only two days treatment squamous metaplastic vaginal epithelium in rats shows a reversal of the epithelium into a normal phenotype which continues after cessation of the treatment for 7 to 11 days. Higher concentrations and longer retention times lead to a statistically significant (p = 0.025) increase in the protection time. These data demonstrate that squamous changes induced by vitamin A deficiency can be totally reversed with topically applied retinyl palmitate.
AuthorsH K Biesalski, U Sobeck, H Weiser
JournalEuropean journal of medical research (Eur J Med Res) Vol. 6 Issue 9 Pg. 391-8 (Sep 28 2001) ISSN: 0949-2321 [Print] Germany
PMID11591530 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anticarcinogenic Agents
  • Vitamin A
  • retinol palmitate
Topics
  • Administration, Topical
  • Animals
  • Anticarcinogenic Agents (pharmacology)
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Epithelium (pathology)
  • Female
  • Metaplasia
  • Ovariectomy
  • Rats
  • Vagina (pathology)
  • Vaginal Diseases (drug therapy, pathology)
  • Vitamin A (analogs & derivatives, pharmacology)

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