Effects of AH-9700, (+)-pentazocine, DTG and oxybutynin on micturition in anesthetized rats with acetone-induced cystitis.

Abstract

We investigated the effects of AH-9700 (1-[2-(3,4-dihydro-6,7-dimethyl-2-naphthalenyl)ethyl] pyrrolidine fumarate; a novel sigma receptor ligand), (+)-pentazocine and 1,3-di-o-tolylguanidine (DTG) (two typical sigma receptor ligands), and oxybutynin (a currently used anti-pollakiuria drug) on cystometrograms in anesthetized rats with 30% acetone-induced cystitis. Compared to sham-treated rats, acetone-treated cystitis models exhibited an increase in urinary frequency during continuous filling cystometry. Intravenous administration of AH-9700 (1-5 mg/kg), (+)-pentazocine or DTG to the rats with cystitis dose-dependently prolonged micturition intervals and increased the micturition threshold pressure. Oxybutynin (1 mg/kg. i.v.) also extended micturition intervals, but decreased the micturition pressure. These results indicate that AH-9700, (+)-pentazocine and DTG improve abnormal frequent urination caused by acetone-induced cystitis in a manner different from that of oxybutynin.

• Authors: I Shimizu, K Kawashima, D Ishii, M Oka
• Journal: Life sciences (Life Sci) Vol. 69 Issue 14 Pg. 1691-7 (Aug 24 2001) ISSN: 0024-3205 [Print] Netherlands
• PMID: 11589509 (Publication Type: Journal Article)

Chemical References

• Fumarates
• Guanidines
• Mandelic Acids
• Naphthalenes
• Acetone
• 1-(2-(3,4-dihydro-6,7-dimethyl-2-naphthalenyl)ethyl) pyrrolidine fumarate
• oxybutynin
• 1,3-ditolylguanidine
• Pentazocine

Topics

• Acetone (adverse effects)
• Anesthesia
• Animals
• Cystitis (chemically induced, physiopathology)
• Disease Models, Animal
• Fumarates (pharmacology)
• Guanidines (pharmacology)
• Male
• Mandelic Acids (pharmacology)
• Naphthalenes (pharmacology)
• Pentazocine (pharmacology)
• Rats
• Rats, Wistar
• Urination (drug effects)