Abstract |
We used infantile neuronal ceroid lipofuscinosis (INCL), in which deterioration of the central nervous system is extremely rapid, to study constant release of an opioid for pains of central origin in a metabolic disease. The effect of a transdermal fentanyl patch was studied in five children with INCL. In two of them, measurements of 17 fentanyl serum concentrations and also visual analogue pain scale were obtained during a 15-day study period. Low doses of transdermal fentanyl usually provided good pain relief for the first two days, but not for the third day, of the three-day patch change interval. Pain relief of this type seems mandatory for pains mostly of central origin.
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Authors | M K Mannerkoski, H J Heiskala, P R Santavuori, J A Pouttu |
Journal | European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
(Eur J Paediatr Neurol)
Vol. 5 Suppl A
Pg. 175-7
( 2001)
ISSN: 1090-3798 [Print] England |
PMID | 11588992
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics, Opioid
- Fentanyl
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Topics |
- Administration, Cutaneous
- Analgesics, Opioid
(administration & dosage)
- Child
- Fentanyl
(administration & dosage)
- Humans
- Neuronal Ceroid-Lipofuscinoses
(complications)
- Pain
(drug therapy, etiology)
- Treatment Outcome
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