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[Zolpidem (ivadal) treatment of sleep disorders].

Abstract
The results of the multicenter study of zolpidem activity, being carried out in inpatient- and out-patient clinics of 20 cities in Russia, are reported. One thousand seventeen patients with transitory, short time and chronic dyssomnia have been included in the trial. Zolpidem (ivadal, "Sanofi-Syntelabo", France) has been prescribed once a day in a dose of 10 mg (one tablet) before going to sleep in a period of two weeks. The efficiency has been assessed by evaluating dyssomnia symptoms according to "Sleep assessment questionnaire" of "Sanofi-Syntelabo" completed by the patients and "Clinical Global Impression Scale" completed by investigators. Safety has been assessed by analyzing a frequency of side effect appearance and changes in vital parameters: blood pressure, heart and breath rate. Zolpidem has been found to reveal high clinical efficiency and safety. By the end of the treatment, 59.5% of the patients experienced no difficulties in falling asleep, in 28.6% of the patients the latter being significantly reduced. On the whole the improvement was in 89.4% patients. No side effects have been observed. Zolpidem is a highly effective and safe medication for different type dyssomnia treatment that can be recommended for application in general clinical practice.
AuthorsIu A Aleksandrovskiĭ, V V Androsova
JournalZhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoĭ promyshlennosti Rossiĭskoĭ Federatsii, Vserossiĭskoe obshchestvo nevrologov [i] Vserossiĭskoe obshchestvo psikhiatrov (Zh Nevrol Psikhiatr Im S S Korsakova) Vol. 101 Issue 9 Pg. 22-6 ( 2001) ISSN: 1997-7298 [Print] Russia
Vernacular TitlePrimenenie zolpidema (ivadala) pri lechenii narusheniĭ sna.
PMID11586699 (Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • GABA Agonists
  • Hypnotics and Sedatives
  • Pyridines
  • zolpidem
Topics
  • Adolescent
  • Adult
  • Aged
  • Chronic Disease
  • GABA Agonists (administration & dosage, therapeutic use)
  • Humans
  • Hypnotics and Sedatives (administration & dosage, therapeutic use)
  • Middle Aged
  • Pyridines (administration & dosage, therapeutic use)
  • Sleep Wake Disorders (diagnosis, drug therapy)
  • Surveys and Questionnaires
  • Treatment Outcome

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