Abstract | OBJECTIVE: METHODS: Alterations in ST mRNA expression in FIGO IB1 cervical cancer ( n = 30) and normal cervixes ( n = 30) were examined by semiquantitative reverse transcription-polymerase chain reaction (RT-PCR). RESULTS:
ST6Gal I expression was enhanced in squamous cell carcinoma of the cervix (P = 0.026, Mann-Whitney U test), but mRNA expression from the other three STs ( ST3Gal I, ST3Gal III, and ST3Gal IV) was significantly down-expressed in squamous cell carcinoma of the cervix compared to the normal cervix (P = 0.003, P < 0.001, and P = 0.001, respectively). High ST6Gal I expression was associated with more invasive properties of cervical cancer, such as deep stromal invasion, lymph or vascular space involvement, and poor differentiation (P = 0.010, P < 0.001, P < 0.001, respectively). CONCLUSIONS:
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Authors | P H Wang, Y F Li, C M Juang, Y R Lee, H T Chao, Y C Tsai, C C Yuan |
Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 83
Issue 1
Pg. 121-7
(Oct 2001)
ISSN: 0090-8258 [Print] United States |
PMID | 11585423
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2001 Academic Press. |
Chemical References |
- Isoenzymes
- RNA, Messenger
- Sialyltransferases
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Topics |
- Carcinoma, Squamous Cell
(enzymology, genetics, pathology)
- Cervix Uteri
(enzymology)
- Female
- Humans
- Isoenzymes
(biosynthesis, genetics)
- Neoplasm Staging
- Prospective Studies
- RNA, Messenger
(biosynthesis, genetics)
- Reverse Transcriptase Polymerase Chain Reaction
- Sialyltransferases
(biosynthesis, genetics)
- Uterine Cervical Neoplasms
(enzymology, genetics, pathology)
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