Tumor angiogenesis induced by granulocyte chemotactic protein-2 as a countercurrent principle.

Abstract

Chemokine production by tumors is a well-known phenomenon, but its role in tumor biology remains debatable. Although intratumoral injection of granulocyte chemotactic protein-2 (GCP-2) had no effect on tumor parameters, needle-free stable expression of the chemokine resulted in enhanced tumor growth. It is shown here that tumors that express a potent form of GCP-2 induce a strong influx and activation of tumor-associated neutrophils. The production of GCP-2 leads to intratumoral expression of gelatinase B and advantage for tumor growth by increased angiogenesis. These results are in line with the countercurrent principle of chemokine action and support the notion that paraneoplastic expression of ELR-positive CXC chemokines has to be blocked rather than stimulated in cancer therapy.

• Authors: E Van Coillie, I Van Aelst, A Wuyts, R Vercauteren, R Devos, C De Wolf-Peeters, J Van Damme, G Opdenakker
• Journal: The American journal of pathology (Am J Pathol) Vol. 159 Issue 4 Pg. 1405-14 (Oct 2001) ISSN: 0002-9440 [Print] United States
• PMID: 11583968 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CXCL6 protein, human
• Chemokine CXCL6
• Chemokines, CXC
• Peptide Fragments
• Recombinant Proteins

Topics

• Animals
• Chemokine CXCL6
• Chemokines, CXC (genetics, physiology)
• Chemotaxis, Leukocyte
• Female
• Gene Transfer Techniques
• Humans
• Injections, Intralesional
• Melanoma (blood supply, pathology, physiopathology)
• Mice
• Mice, Nude
• Neoplasm Transplantation
• Neovascularization, Pathologic (etiology)
• Neutrophils (physiology)
• Peptide Fragments (physiology)
• Recombinant Proteins
• Skin Neoplasms (blood supply, pathology, physiopathology)
• Transfection