Anti-tumor promoting effects of multiflorane-type triterpenoids and cytotoxic activity of karounidiol against human cancer cell lines.

Abstract

Forty-nine multiflorane-type triterpenoids consisting of 11 compounds isolated from the seeds of Trichosanthes kirilowii (Cucurbitaceae) and 38 of their derivatives have been evaluated for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in Raji cells as a primary screening test for anti-tumor promoters. All of the compounds tested showed an inhibitory effect against EBV-EA activation, and among which 43 were revealed to possess remarkable activity with potencies either comparable to or stronger than that of glycyrrhetic acid, a known natural anti-tumor promoter. Their structure-activity relationship is discussed. Evaluation of the cytotoxic activity of karounidiol (27) against human cancer cell lines exhibited cytotoxicity especially against a human renal cancer.

• Authors: T Akihisa, H Tokuda, E Ichiishi, T Mukainaka, M Toriumi, M Ukiya, K Yasukawa, H Nishino
• Journal: Cancer letters (Cancer Lett) Vol. 173 Issue 1 Pg. 9-14 (Nov 08 2001) ISSN: 0304-3835 [Print] Ireland
• PMID: 11578803 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticarcinogenic Agents
• Antigens, Viral
• Epstein-Barr virus early antigen
• Triterpenes
• karounidiol
• Tetradecanoylphorbol Acetate

Topics

• Anticarcinogenic Agents (chemistry, pharmacology)
• Antigens, Viral (metabolism)
• Cucurbitaceae (chemistry)
• Drug Screening Assays, Antitumor
• Humans
• Neoplasms (prevention & control)
• Seeds (chemistry)
• Structure-Activity Relationship
• Tetradecanoylphorbol Acetate (pharmacology)
• Triterpenes (chemistry, pharmacology)
• Tumor Cells, Cultured