Effect of germanium-132 on low-density lipoprotein oxidation and atherosclerosis in Kurosawa and Kusanagi hypercholesterolemic rabbits.

Abstract

Germanium-132 (Ge-132) was given at 200 mg/kg of body weight to 8-week-old Kurosawa and Kusanagi hypercholesterolemic (KHC) rabbits. Thirty-six weeks later, the susceptibility of plasma low-density lipoprotein to oxidation and the morphology of atherosclerosis in the aorta and coronary artery were investigated. Treatment with Ge-132 resulted in decreases in the oxidation rate and in the formation rate of thiobarbituric acid-reactive substances following copper-induced oxidation of LDL. Ge-132 is suggested to possess antioxidative properties, but this did not lead to any attenuation of atherosclerotic progression in the KHC rabbits.

• Authors: Y Wakabayashi
• Journal: Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 65 Issue 8 Pg. 1893-6 (Aug 2001) ISSN: 0916-8451 [Print] England
• PMID: 11577738 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticholesteremic Agents
• Lipoproteins, LDL
• Organometallic Compounds
• Propionates
• Thiobarbituric Acid Reactive Substances
• Germanium
• propagermanium

Topics

• Aging (pathology)
• Animals
• Anticholesteremic Agents (pharmacology)
• Aorta, Thoracic (pathology)
• Arteriosclerosis (blood)
• Female
• Germanium
• Hypercholesterolemia (blood, pathology)
• Kinetics
• Lipoproteins, LDL (blood)
• Organometallic Compounds (pharmacology)
• Oxidation-Reduction
• Oxidative Stress
• Propionates
• Rabbits
• Thiobarbituric Acid Reactive Substances (metabolism)