A new isoquinoline alkaloid from the marine sponge Haliclona species.

Abstract

Two isoquinoline alkaloids, including the new compound 1, were isolated from the cytotoxic fractions of an aqueous extract of the marine sponge Haliclona sp. The structures of these compounds were established as 1-hydroxymethyl-7-methoxyisoquinolin-6-ol (1) and mimosamycin (2) by conventional spectroscopic methods and by comparison with related compounds. Mimosamycin (2) was the principal cytotoxin with an IC(50) of approximately 10 microg/mL against melanoma and ovarian human tumor cell lines.

• Authors: M A Rashid, K R Gustafson, M R Boyd
• Journal: Journal of natural products (J Nat Prod) Vol. 64 Issue 9 Pg. 1249-50 (Sep 2001) ISSN: 0163-3864 [Print] United States
• PMID: 11575970 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• 1-hydroxymethyl-7-methoxyisoquinolin-6-ol
• Alkaloids
• Antineoplastic Agents
• Isoquinolines
• mimosamycin

Topics

• Alkaloids (chemistry, isolation & purification, pharmacology)
• Animals
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Chromatography, High Pressure Liquid
• Dose-Response Relationship, Drug
• Drug Screening Assays, Antitumor
• Female
• Humans
• Inhibitory Concentration 50
• Isoquinolines (chemistry, isolation & purification, pharmacology)
• Magnetic Resonance Spectroscopy
• Melanoma
• Molecular Structure
• Ovarian Neoplasms
• Philippines
• Porifera (chemistry)
• Spectrophotometry, Infrared
• Tumor Cells, Cultured (drug effects)