Midazolam versus propofol for reducing contractility of fatigued canine diaphragm.
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| Abstract |
The effects of midazolam and propofol on the contractility of fatigued canine diaphragm were examined. Diaphragmatic fatigue was induced by intermittent supramaximal bilateral electrophrenic stimulation at a frequency of 20 Hz applied for 30 min. After fatigue had been induced, group I (n=10) received no study drug, group II (n=10) was given a propofol infusion (0.1 mg kg(-1) loading dose plus 1.5 mg kg(-1) h(-1) maintenance dose) and group III (n=10) was given a midazolam infusion (0.1 mg kg(-1) loading dose plus 0.1 mg kg(-1) h(-1) maintenance dose). Diaphragmatic contractility was assessed by measuring transdiaphragmatic pressure (Pdi). After the fatigue-inducing period in each group, Pdi at low-frequency (20 Hz) stimulation was lower than the baseline values (P<0.05), whereas no change in Pdi at high-frequency (100 Hz) stimulation was observed. In group II, Pdi at 20 Hz stimulation was lower than fatigued values (P<0.05); Pdi at 100 Hz stimulation did not change. In group III, Pdi at both stimulation frequencies was lower than fatigued values (P<0.05). Compared with group I, Pdi at 20 Hz stimulation was lower than fatigued values (P<0.05) during administration of the study drug in groups II and III. The decrease in Pdi was greater in group III than in group II (P<0.05). In conclusion, midazolam compared with propofol is associated with an inhibitory effect on contractility in the fatigued canine diaphragm.
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| Authors | Y Fujii, H Toyooka |
| Journal | British journal of anaesthesia (Br J Anaesth) Vol. 86 Issue 6 Pg. 879-81 (Jun 2001) ISSN: 0007-0912 [Print] England |
| PMID | 11573601 (Publication Type: Comparative Study, Journal Article, Retracted Publication) |
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