A multicentric study with arteether in patients of uncomplicated falciparum malaria.

Abstract

Two hundred and sixty seven patients of uncomplicated P. falciparum malaria completed study in a multicentric phase III clinical trial of Arteether. Arteether was given intramuscularly in a dose of 150 mg daily for three consecutive days. Each patient was followed upto 28 days of alpha, beta arteether therapy. The cure rate was 97% with fever clearance time between 1-7 days (24-168 hours) and parasite clearance time between 1-3 days (24-72 hours). Parasite reappearance rate was found to be 3% and reported at only three of the centres. Following the treatment no adverse effect was observed on haematological, biochemical and vital clinical parameters.

• Authors: O P Asthana, J S Srivastava, V P Kamboj, N Valecha, V P Sharma, S Gupta, T K Pande, K A Vishwanathan, K M Mahapatra, N C Nayak, P K Mahapatra, J Mahanta, V K Srivastava, Vasdev, N Singh, M M Shukla, A B Balsara, S K Mishra, S K Satpathy, S Mohanty, B Dash
• Journal: The Journal of the Association of Physicians of India (J Assoc Physicians India) Vol. 49 Pg. 692-6 (Jul 2001) ISSN: 0004-5772 [Print] India
• PMID: 11573553 (Publication Type: Clinical Trial, Clinical Trial, Phase III, Journal Article, Multicenter Study)

Chemical References

• Antimalarials
• Artemisinins
• Sesquiterpenes
• artemotil

Topics

• Adolescent
• Adult
• Aged
• Antimalarials (therapeutic use)
• Artemisinins
• Female
• Humans
• Malaria, Falciparum (drug therapy)
• Male
• Middle Aged
• Sesquiterpenes (therapeutic use)