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Salivary duct carcinoma--a highly aggressive salivary gland tumor with HER-2/neu oncoprotein overexpression.

AbstractSalivary duct carcinoma (SDC) is a highly malignant salivary gland tumor with aggressive clinical behavior, and is characterized by its histological resemblance to invasive ductal carcinoma of the breast. Overexpression and/or amplification of proto-oncogene Her2/neu has been shown to influence both prognosis and treatment of breast cancer. Since salivary duct carcinoma and ductal breast carcinoma share many common characteristics, HER2/neu overexpression might also be important in SDC. However, data on the expression of c-erbB2/HER2/neu in salivary gland tumors are still scarce. Therefore, we have evaluated 15 cases of salivary duct carcinomas (SDC) for HER2/neu overexpression using immunohistochemistry with the HercepTest. Overexpression, identified as strong or moderate membrane immunostaining, was observed in all but one case of SDC in most neoplastic cells. Thus, our study suggests that anti-HER2/neu therapy with Herceptin is beneficial for patients with aggressive salivary duct carcinoma.
AuthorsA Skálová, Stárek, V Kucerová, P Szépe, L Plank (Affiliation: Department of Pathology, Medical Faculty, Charles University, Plzen, Czech Republic. skalova at fnplzen.cz)
JournalPathology, research and practice (Pathol Res Pract) Vol. 197 Issue 9 Pg. 621-6 ( 2001) ISSN: 0344-0338 [Print] Germany
PMID11569926 (Publication Type: Journal Article)
Chemical References
  • Antibodies, Monoclonal
  • Antigens, Nuclear
  • Antineoplastic Agents
  • Nuclear Proteins
  • Reagent Kits, Diagnostic
  • Tumor Markers, Biological
  • trastuzumab
  • Receptor, erbB-2
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Antibodies, Monoclonal (therapeutic use)
  • Antigens, Nuclear
  • Antineoplastic Agents (therapeutic use)
  • Cell Count
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Lymph Nodes (pathology)
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Nuclear Proteins (analysis)
  • Reagent Kits, Diagnostic
  • Receptor, erbB-2 (analysis, biosynthesis)
  • Salivary Gland Neoplasms (metabolism, pathology, therapy)
  • Tumor Markers, Biological (analysis)

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